{"id":2,"date":"2022-09-14T15:36:50","date_gmt":"2022-09-14T14:36:50","guid":{"rendered":"https:\/\/blogs.glowscotland.org.uk\/gc\/hhgenomeandmutations\/?page_id=2"},"modified":"2022-09-15T11:48:23","modified_gmt":"2022-09-15T10:48:23","slug":"sample-page","status":"publish","type":"page","link":"https:\/\/blogs.glowscotland.org.uk\/gc\/hhgenomeandmutations\/","title":{"rendered":"Genome and Mutations"},"content":{"rendered":"<p><strong>The following links offer some useful revision on Cell Structure to support your learning:<\/strong><\/p>\n<p><a href=\"https:\/\/www.bbc.co.uk\/bitesize\/guides\/zc499j6\/revision\/1\">BBC Bitesize Learner Guide<\/a><\/p>\n<p><a href=\"https:\/\/www.bbc.co.uk\/bitesize\/guides\/zc499j6\/test\">BBC Bitesize Questions<\/a><\/p>\n<p><a href=\"https:\/\/www.youtube.com\/watch?v=8upvT_Zv0CE&amp;list=PLh6Kfjy_tmxIdvPTFcwUpMbtARoJINl9j&amp;index=5\">Biology Coach Video Lesson<\/a><\/p>\n<p><a href=\"https:\/\/thehigherbiologypodcast.buzzsprout.com\/1049158\/7321285-mutations-with-prof-nathan-lents\">The Higher Biology Podcast &#8211; Mutations<\/a><\/p>\n<p><a href=\"https:\/\/forms.office.com\/Pages\/ResponsePage.aspx?id=oyzTzM4Wj0KVQTctawUZKcnB7Pp09UlJk_HVluJLXeJUQkg3REFTQkkzTE5UTFU3NkdRN09NWlhMMS4u\">Mutations Quiz<\/a><\/p>\n<p><a href=\"https:\/\/blogs.glowscotland.org.uk\/gc\/public\/hhgenomeandmutations\/uploads\/sites\/11715\/2022\/09\/15114143\/Unit-1.4-Mutations.docx\">Mutations Mindmap<\/a><\/p>\n<p><a href=\"https:\/\/www.flashcardmachine.com\/machine\/?read_only=3577611&amp;p=3f6p\">Online Flashcards<\/a><\/p>\n<p><strong>At Higher, you will need to know the following:<\/strong><\/p>\n<ul>\n<li class=\"p1\">Proteins are held in a three dimensional shape by peptide bonds, hydrogen bonds, interactions between individual amino acids.<\/li>\n<li class=\"p1\">Proteins have a large variety of structures and shapes resulting in a wide range of functions.<\/li>\n<li class=\"p1\">Polypeptide chains fold to form the three dimensional shape of the protein.<\/li>\n<li class=\"p1\">Amino acids are linked by peptide bonds to form polypeptides.<\/li>\n<li class=\"p1\">Mutations result in no protein or a faulty protein being expressed.<\/li>\n<li class=\"p1\">Genetic disorders are caused by changes to genes or chromosomes that result in the proteins not being expressed or the proteins expressed not functioning correctly<\/li>\n<li class=\"p1\">Single gene mutations involve the alteration of a DNA nucleotide sequence as a result of the substitution, insertion or deletion of nucleotides.<\/li>\n<li class=\"p1\">Nature of single-nucleotide substitutions including: missense, nonsense and splice-site mutations. Missense (replacing one amino acid codon with another), nonsense (replacing an amino acid codon with a premature stop codon \u2014 no amino acid is made and the process stops) and splice-site mutations (creating or destroying the codons for exon\/intron splicing).<\/li>\n<li class=\"p1\">Nucleotide insertions or deletions result in frame-shift mutations or an expansion of a nucleotide sequence repeat.<\/li>\n<li class=\"p1\">The effect of these mutations on the structure and function of the protein synthesised and the resulting effects on health.<\/li>\n<li class=\"p1\">Chromosome structure mutations. The structure of a chromosome can be altered. These mutations can take the form of a deletion (loss of a segment of a chromosome), duplication (repeat of as egment of a chromosome) or translocation (the rearrangement of chromosomal material involving two or more chromosomes).<\/li>\n<\/ul>\n","protected":false},"excerpt":{"rendered":"<p>The following links offer some useful revision on Cell Structure to support your learning: BBC Bitesize Learner Guide BBC Bitesize Questions Biology Coach Video Lesson The Higher Biology Podcast &#8211; Mutations Mutations Quiz Mutations Mindmap Online Flashcards At Higher, you will need to know the following: Proteins are held in a three dimensional shape by &hellip; <a href=\"https:\/\/blogs.glowscotland.org.uk\/gc\/hhgenomeandmutations\/\" class=\"more-link\">Continue reading<span class=\"screen-reader-text\"> &#8220;Genome and Mutations&#8221;<\/span><\/a><\/p>\n","protected":false},"author":6619,"featured_media":0,"parent":0,"menu_order":0,"comment_status":"closed","ping_status":"open","template":"","meta":{"footnotes":""},"class_list":["post-2","page","type-page","status-publish","hentry"],"_links":{"self":[{"href":"https:\/\/blogs.glowscotland.org.uk\/gc\/hhgenomeandmutations\/wp-json\/wp\/v2\/pages\/2","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/blogs.glowscotland.org.uk\/gc\/hhgenomeandmutations\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/blogs.glowscotland.org.uk\/gc\/hhgenomeandmutations\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/blogs.glowscotland.org.uk\/gc\/hhgenomeandmutations\/wp-json\/wp\/v2\/users\/6619"}],"replies":[{"embeddable":true,"href":"https:\/\/blogs.glowscotland.org.uk\/gc\/hhgenomeandmutations\/wp-json\/wp\/v2\/comments?post=2"}],"version-history":[{"count":3,"href":"https:\/\/blogs.glowscotland.org.uk\/gc\/hhgenomeandmutations\/wp-json\/wp\/v2\/pages\/2\/revisions"}],"predecessor-version":[{"id":11,"href":"https:\/\/blogs.glowscotland.org.uk\/gc\/hhgenomeandmutations\/wp-json\/wp\/v2\/pages\/2\/revisions\/11"}],"wp:attachment":[{"href":"https:\/\/blogs.glowscotland.org.uk\/gc\/hhgenomeandmutations\/wp-json\/wp\/v2\/media?parent=2"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}